The N-terminal domain is conserved in all members of the IGF-binding proteinsuperfamily.
2
Tubulins are a universally conserved proteinsuperfamily that carry out diverse biological roles by assembling filaments with very different architectures.
3
Genomic enzymology is the study of protein structure-function in light of genetic context and evolution of proteinsuperfamilies.
4
We present an update of ligand binding in large proteinsuperfamilies and identify those ligands most frequently utilized by nature.
5
Efflux pump gene proteinsuperfamilies have been characterized by genome analysis of drug resistant strains and through in vitro transcriptional studies.
1
It assists and guides the user in building proteinhomology models at different levels of complexity.
2
Genomes were annotated and proteinhomologies were determined by Blast and HHPred.
3
Proteinhomology search revealed that the three Legionella enzymes and P. fluorescens PC-PLC share conserved domains also present in uncharacterized fungal proteins.
1
Conclusion: The analysis of genomic occurrences of CATH 2.4 protein homologoussuperfamilies and topologies has revealed the power-law character of their distributions.